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In general, dogs with Addison's may experience recurrent bouts of gastroenteritis, poor appetite, slow loss of body condition, and an inability to respond appropriately to stress. It's important to note that the symptoms of Addison's disease may wax and wane. Reduction in aldosterone production has a pronounced impact on the body. It leads to changes in serum levels of sodium, chloride, and potassium, which affects the kidneys. This in turn leads to problems with the heart and circulatory system. Cortisol, the other major steroid hormone affected by Addison's, plays a role in almost every important tissue in the dog's body. It regulates the production of glucose, regulates metabolism, influences the breakdown of fat and proteins, regulates blood pressure, suppresses inflammation, stimulates the formation of red blood cells, and counteracts stress. Reduction in the production of aldosterone and cortisol causes the symptoms that pet owners and veterinarians most commonly see with the disease.
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